The main campus, located at 1234 Columbus Avenue, is adjacent to Malcolm X Boulevard and Cedar Streets. This 16-acre campus consists of five buildings: Administration, Academic, Media Arts, Student Center, and the Reggie Lewis Track and Athletic Center.

The Columbus Avenue Roxbury Crossing Campus includes six buildings housing classrooms, specialized science and computer laboratories, the Library and the Learning Center, an onsite Day Care Center, a student bookstore, the Reggie Lewis Track and Athletic Center, a 500 seat theater, music, dance and art studios, a new food service court, snack machines and dedicated spaces for student activities, quiet games, student lounges and small group meeting spaces.